For treatment-naïve and virologically suppressed adults with HIV-1. See Full Indication.

DOSING AND DRUG

INTERACTIONS OF DOVATO

DOSING AND DRUG INTERACTIONS OF DOVATO

Dosing Of DOVATO

A Complete Regimen Offering Convenient Dosing for Your Adult Patients

ONCE A DAY

TAKEN ANY TIME OF DAY

WITH OR WITHOUT FOOD

Potential Drug Interactions With DOVATO

Established and Other Potentially Significant Drug to Drug Interactions

AVOID

Contraindicated
Dofetilide
Avoid Coadministration
Agent Recommendations

Oxcarbazepine

Phenobarbital

Phenytoin

St John's wort (Hypericum perforatum)

Avoid coadministration with DOVATO because there are insufficient data to make dosing recommendations
Sorbitol When possible, avoid use of sorbitol-containing medicines with DOVATO
  • Because DOVATO is a complete regimen, coadministration with other ARVs for the treatment of HIV-1 infection is not recommended

ARVs=antiretrovirals.

CONSIDERATIONS

Dosing Adjustments and Considerations
Agent Recommendations
Certain UGT1A/CYP3A inducers: carbamazepine or rifampin An additional dolutegravir 50-mg dose should be taken, separated by 12 hours from DOVATO 
Metformin
Refer to the prescribing information for metformin for assessing the benefit and risk of concomitant use of DOVATO and metformin
Medications containing polyvalent cations (eg, Mg or Al): cation-containing antacids or laxatives, sucralfate, or buffered medications Administer DOVATO 2 hours before or 6 hours after taking medications containing polyvalent cations
Oral calcium or iron supplements, including multivitamins containing calcium or iron
When taken with food, DOVATO and supplements or multivitamins containing calcium or iron can be taken at the same time. Under fasting conditions, DOVATO should be taken 2 hours before or 6 hours after taking supplements containing calcium or iron    
Dalfampridine
Elevated levels of dalfampridine increase the risk of seizures. The potential benefits of taking dalfampridine concurrently with DOVATO should be considered against the risk of seizures in these patients
  • Please see Section 7 of the full Prescribing Information for additional drug interaction information

Al=aluminum; Mg=magnesium.

NO ADJUSTMENTS

Dolutegravir and Lamivudine, Components of DOVATO, Have No Clinically Relevant Effects on the Pharmacokinetics of the Following Agents

Based on available pharmacokinetics drug interaction studies
  • Prednisone
  • Midazolam
  • Rifabutin
  • Oral contraceptives containing norgestimate* and ethinyl estradiol
  • Proton pump inhibitors (omeprazole)
Based on pharmacokinetics, metabolic pathways, and/or available drug interaction studies

Hepatitis C drugs, including1,2:

  • Sofosbuvir
  • Ledipasvir/sofosbuvir3
  • Simeprevir4
  • Elbasvir/grazoprevir5
  • Daclatasvir plus sofosbuvir
  • Ombitasvir/paritaprevir/r plus dasabuvir6
  • Sofosbuvir/velpatasvir
  • Sofosbuvir/velpatasvir/voxilaprevir7
  • Glecaprevir/pibrentasvir8
  • Ombitasvir/paritaprevir/r plus dasabuvir6
  • Sofosbuvir/velpatasvir
  • Sofosbuvir/velpatasvir/voxilaprevir7
  • Glecaprevir/pibrentasvir8

Norelgestromin is the active metabolite of norgestimate and no drug interaction is expected with norgestimate.9

References:

  1. AIDSinfo website. https://aidsinfo.nih.gov/contentfiles/lvguidelines/adultandadolescentgl.pdf. Accessed July 16, 2020.
  2. American Association for the Study of Liver Diseases and Infectious Diseases Society of America. HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. https://www.hcvguidelines.org/unique-populations/hiv-hcv. Updated May 24, 2018. Accessed July 16, 2020.
  3. Harvoni [package insert]. Foster City, CA: Gilead Sciences, Inc.; 2017.
  4. Olysio [package insert]. Titusville, NJ: Janssen Therapeutics; 2017.
  5. Zepatier [package insert]. Whitehouse Station, NJ: Merck & Co, Inc.; 2018.
  6. Viekira Pak [package insert]. North Chicago, IL: AbbVie, Inc.; 2018.
  7. Vosevi [package insert]. Foster City, CA: Gilead Sciences, Inc.; 2017.
  8. Mavyret [package insert]. North Chicago, IL: AbbVie, Inc.; 2018.
  9. Song IH, Borland J, Chen S, Wajima T, Peppercorn AF, Piscitelli SC. Dolutegravir has no effect on the pharmacokinetics of oral contraceptives with norgestimate and ethinyl estradiol. Ann Pharmacother. 2015;49(7):784–789.

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